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ea0070aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Immunomodulatory and anti-diabetic actions of a structurally-modified analogue of esculentin-2CHa isolated from the skin secretion of the frog, lithobates chiricahuensis (ranidae)

Ojo Opeolu , Ofosu Wendy , Abiodun Falobi Ayodele , Benjamin Falana Ayokunle , Sen Monica , Smyth Lesley

Aim: Our previousstudies have shown evidence for insulin-releasing actions of some amphibian skin peptides; including esculentin-2CHa. However, there is a need to further improve the potency of some of this peptides and to characterize their other beneficial effects. This study investigates the effect of a Leu31→Lys substitution on the insulin-releasing and immunomodulatory effects of esculentin-2CHa.Methods: BRIN-BD11 cells were incubat...

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ea0090oc10.2 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2023

Characterization of the insulinotropic and glucose lowering actions of hybridized amphibian host defence peptide, tigerinin-1R

Abiodun Falobi Ayodele , Edeani Joy Nneka , Ofosu Wendy Amy , Smyth Lesley , Corcoran Olivia , Dunmore Simon , Ojo Opeolu

Aim: Our previous studies indicated the potential antidiabetic actions of the amphibian host-defence peptide, tigerinin-1. Tigerinin-1R was conjugated with gastric inhibitory polypeptide (GIP) as part of strategies for further development of its therapeutic effects. This study characterises the insulin-releasing and cytotoxic properties of the resulting hybrid peptide.Method: Pure G-TGN was commercially synthesized G-TGN. Insulin releasing effects were a...

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Endocrine Abstracts

Immunomodulatory and anti-diabetic actions of a structurally-modified analogue of esculentin-2CHa isolated from the skin secretion of the frog, lithobates chiricahuensis (ranidae)

Characterization of the insulinotropic and glucose lowering actions of hybridized amphibian host defence peptide, tigerinin-1R

BiosciAbstracts